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Di laman Vaksin:
"Vaksin dikenali dalam sejarah sebagai suatu cara yang berkesan untuk melawan dan membasmi penyakit berjangkit, namun keberkesanannya ada juga batasnya.[1] Perlindungan kadangkalanya gagal kerana sistem imun badan tidak dapat bertindak balas dengan secukupnya mahupun secara langsung. Tindak balas yang kurang biasanya berlaku daripada faktor-faktor kesihatan yang wujud seperti diabetes, penggunaan steroid, HIV ataupun usia.[perlu rujukan] Vaksin boleh juga gagal berkesan disebabkan faktor genetik seperti tiadanya strain sel B yang boleh menghasilkan antibodi yang sesuai bertindak balas serta bergabung dengan antigen yang menghasilkan patogen.
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