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Di laman Talasemia:
"Biasanya, majoriti hemoglobin dewasa (HbA) terdiri daripada empat rantai protein, dua rantai α dan dua β-globin yang disusun menjadi heterotetramer. Dalam talasemia, pesakit mempunyai kecacatan sama ada pada rantai α atau β-globin, menyebabkan pengeluaran sel darah merah yang tidak normal.[perlu rujukan]
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