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Di laman Transaminase:
"Haiwan mesti memetabolismekan protein kepada asid amino dengan mengorbankan tisu otot apabila gula darah rendah. Keutamaan transaminase hati terhadap oksaloasetat atau alfa-ketoglutarat memainkan peranan penting dalam menyalurkan nitrogen daripada metabolisme asid amino kepada aspartat dan glutamat bagi penukaran kepada urea dalam perkumuhan nitrogen. Dalam cara yang sama, dalam otot, penggunaan piruvat bagi transaminasi memberikan alanina yang dibawa oleh aliran darah ke hati (tindak balas keseluruhan dipanggil kitaran glukosa-alanina). Di sini, transaminase lain menjana semula piruvat yang menyediakan bahan pelopor berharga untuk glukoneogenesis. Kitaran alanina ini serupa dengan kitaran Cori yang membolehkan metabolisme anaerobik oleh otot.[perlu rujukan]
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