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In page Hazel Sive:

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Sive has conducted research into nervous system patterning.[citation needed] She was involved in the development of subtractive cloning techniques used to define nervous system molecular markers and regulators in Xenopus frogs and the zebrafish Danio. Expression of these genes determine the point at which an embryo begins to develop a nervous system: Sive determined that future brain cells are set aside when the embryo is just a ball of cells.[citation needed] Sive was the first to use hormone-inducible fusion proteins to study these genes.[3]