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In page Persistent, bioaccumulative and toxic substances:

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Similar to POPs classification, the PBT classification of chemicals was developed in 1997 by the Great Lakes Binational Toxic Strategy (GLBNS). Signed by both the US and Canada, the GLBNS classified PBTs in one of two categories, level I and level II.[citation needed] Level I PBTs are top priority which currently, as of 2005, contained 12 compounds or classes of compounds.[2]