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In page Dendroclimatology:

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Non-climate factors include soil, tree age, fire, tree-to-tree competition, genetic differences, logging or other human disturbance, herbivore impact (particularly sheep grazing), pest outbreaks, disease, and CO2 concentration. For factors which vary randomly over space (tree to tree or stand to stand), the best solution is to collect sufficient data (more samples) to compensate for confounding noise. Tree age is corrected for with various statistical methods: either fitting spline curves to the overall tree record or using similar aged trees for comparison over different periods (regional curve standardization). Careful examination and site selection helps to limit some confounding effects, for example picking sites undisturbed by modern man.[citation needed]