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In page Copper in biology:
"Wilson's disease is produced by mutational defects of a protein that transports copper from the liver to the bile for excretion.[1] The disease involves poor incorporation of copper into ceruloplasmin and impaired biliary copper excretion and is usually induced by mutations impairing the function of the Wilson copper ATPase. These genetic mutations produce copper toxicosis due to excess copper accumulation, predominantly in the liver and brain and, to a lesser extent, in kidneys, eyes, and other organs.[citation needed]
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