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In page Computer-aided diagnosis:

"

Region growing approach is a method of detecting neighboring pixels with similarities. A seed point is required for such method to start. Two elements are needed for this technique to work: similarity and spatial proximity. A neighboring pixel to the seed pixel with similar intensity is likely to be the same type and will be added to the growing region. One disadvantage of this technique is that it requires manual selection of seed point, which introduces bias and inconsistency in the algorithm.[3] This technique is also being used in optic disc identification.[citation needed]