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In page Arteriovenous oxygen difference:
"Arterial blood will generally contain an oxygen concentration of around 20 mL/100 mL.[1] Venous blood with an oxygen concentration of 15 mL/100 mL would therefore lead to typical values of the a-vO2 diff at rest of around 5 mL/100 mL. During intense exercise, however, the a-vO2 diff can increase to as much as 16 mL/100 mL due to the working muscles extracting far more oxygen from the blood than they do at rest.[citation needed]
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