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In page Syndemic:

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Diseases regularly interact and this interaction influences disease course, expression, severity, transmission, and diffusion. Interaction among diseases may be both indirect (changes caused by one disease that facilitate another through an intermediary) and direct (diseases act in direct tandem).[citation needed]

  • When one disease diminishes or eradicates another it is a counter-syndemic disease interaction.[citation needed]
  • The linkage also may not be clear, despite apparent syndemic interactions among diseases, as for example in type 2 diabetes mellitus and hepatitis C virus infection.[citation needed]