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In page Cellular cardiomyoplasty:
"Presently, the success of adult stem cells in regenerating human myocardium is just a fraction of what it could be. Three major challenges have been observed. Adult stem cells exhibit a minimal commitment to engraft into the damaged myocardium, they have low survival rates and they have limited proliferation.[1] The positive effects observed in clinical trials today are a result of the work of donated stem cells that persist in the damaged myocardium for just days to weeks after delivery. Clearly, if cell survival is prolonged, these effects could be greatly enhanced.[citation needed] This is where a majority of research is being done today and several methodologies hold great promise.[2][3]
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