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In page Center for Cerebrovascular Research:

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The CCR is a participating in the first attempt at studying brain arteriovenous malformation (BAVM) management using a randomized controlled clinical trial.[1][2] This multi-center trial (ARUBA: A Randomized Trial of Unruptured Brain Arteriovenous Malformations) has been funded by the National Institute of Neurological Disorders and Stroke (NINDS). The goal of the project is to test the null hypothesis that treatment, by means of interventional procedures, surgery, or radiotherapy offers no difference in the risk of death or symptomatic stroke, and no better functional outcome than does conservative management at five years from discovery of an unruptured brain arteriovenous malformation (BAVM).[citation needed]