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In page Ceftaroline fosamil:
"MRSA can develop resistance to ceftaroline through the alteration of penicillin-binding proteins. Amino acid-altering mutations in the ceftaroline-binding pocket of the transpeptidase region of penicillin-binding protein 2a (PBP2a) confer resistance to ceftaroline.[8] Ceftaroline- and methicillin-resistant strains of S. aureus have been identified in Europe and Asia, but have not been identified in the United States.[9] While cephalosporinases (a type of beta-lactamase that inactivates cephalosporins) confers resistance to other cephalosporins, cephalosporinases have not yet been identified as a mechanism of resistance to ceftaroline.[citation needed]
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