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In page Copper in biology:

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Ongoing research into Menkes disease is leading to a greater understanding of copper homeostasis,[7] the biochemical mechanisms involved in the disease, and possible ways to treat it.[8] Investigations into the transport of copper across the blood/brain barrier, which are based on studies of genetically altered mice, are designed to help researchers understand the root cause of copper deficiency in Menkes disease. The genetic makeup of transgenic mice is altered in ways that help researchers garner new perspectives about copper deficiency. The research to date has been valuable: genes can be turned off gradually to explore varying degrees of deficiency.[citation needed]