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In page Autoimmune regulator:

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In the thymus, the autoimmune regulator (AIRE) induces the transcription of a broad array of organ-specific genes, resulting in the production of proteins that are normally restricted to peripheral tissues. This ectopic expression creates an "immunological self-shadow" that exposes developing T cells to peripheral antigens, thereby facilitating the negative selection of self-reactive T cells and promoting central tolerance. This discovery was achieved through the combined efforts of researchers in Diane Mathis' lab— including Mark Anderson (immunologist)—and those in the Christopher Goodnow lab, where Adrian Liston led this work.[citation needed]