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"CYP17A1 functions in steroidogenesis, where it converts pregnenolone and progesterone to their 17α-hydroxy forms. The enzyme itself is attached to the smooth endoplasmic reticulum of the steroid-producing cells of the adrenal cortex and gonads. CYP17A1 functions as both a 17α-hydroxylase and a 17,20-lyase. The dual activities mediate three key transformations in cortisol and sex hormone synthesis:[citation needed]
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