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PFO is linked to stroke, sleep apnea, migraine with aura, cluster headache, decompression sickness, Raynaud's phenomenon, hyperventilation syndrome, transient global amnesia (TGA), and leftsided carcinoid heart disease (mitral valve). No cause is established for a foramen ovale to remain open instead of closing, but heredity and genetics may play a role.^[3]^[4] In rats research showed a link to the amount of Cryptosporidium infestation and the number of newborn rats that failed to close their foramen ovale. PFO is not treated in the absence of other symptoms.^{[citation needed]}

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