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In page Cardiorenal syndrome:

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Diagnosing cardiorenal syndrome (CRS) is challenging due to the complex and interconnected nature of cardiac and renal dysfunction.[citation needed] It is critical to diagnose CRS at an early stage in order to achieve optimal therapeutic efficacy. There is no specific test to diagnose cardiorenal syndrome. Instead, diagnosis relies on clinical evaluation, laboratory data, and imaging, often in the context of known heart failure, kidney disease, or both.[1] The diagnosis of heart failure requires the presence of clinical signs and symptoms supported by evidence of a structural or functional cardiac abnormality. This diagnostic requirement for cardiorenal syndrome includes similar evidence for both the heart and kidneys.[2]