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In page Chain of survival:

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According to the American Heart Association, out-of-hospital cardiac arrest can affect more than 300,000 people in the United States each year.[1] Three minutes after the onset of cardiac arrest, a lack of blood flow starts to damage the brain, and 10 minutes after, the chances of survival are low.[2] Therefore, bystanders have only a few minutes to act to optimize a person's chances of survival and recovery.[citation needed]