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In page Central nervous system disease:

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Degenerative spinal disorders involve a loss of function in the spine. Pressure on the spinal cord and nerves may be associated with herniation or disc displacement. Degenerative spinal disorders can be primarily caused by the natural aging process and wear and tear of the spine over time. However, other factors can accelerate or contribute to these conditions, such as injury, repetitive strain, genetics, and tumors.[1] Brain degeneration also causes central nervous system diseases (i.e. Alzheimer's, Lewy body dementia, Parkinson's, and Huntington's diseases).[citation needed] Raji et al 2010 reported correlation between obesity and brain degeneration and tissue loss.[2]