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In page Ataxia–telangiectasia:

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As lymphocytes develop from stem cells in the bone marrow into mature lymphocytes in the periphery, they rearrange special segments of their DNA [V(D)J recombination process]. This process requires them to make DSBs, which are difficult to repair in the absence of ATM.[5][6][7][8] As a result, most people with A–T have reduced numbers of lymphocytes and some impairment of lymphocyte function (such as an impaired ability to make antibodies in response to vaccines or infections). In addition, broken pieces of DNA in chromosomes involved in the aforementioned rearrangements tend to recombine with other genes (translocation), making the cells prone to the development of cancer (lymphoma and leukemia).[citation needed]