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In page Smoke inhalation:

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Carbon monoxide (СО), which is absorbed by the lungs, diffuses into the capillaries and dissolves in the plasma and erythrocytes, binding to hemoglobin. As its affinity is more than 200 times that of oxygen, the amount of oxygen bound to hemoglobin is reduced, leading to anoxia.[1] In addition, carbon monoxide released at the tissue level binds to mitochondrial enzyme systems, resulting in the inability of cells to utilize oxygen. When exposed to excess CO, one of the body's natural reactions is to breathe faster. This further increases the CO level in the blood, eventually leading to cardiac arrest.[citation needed]