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In page Suxamethonium chloride:

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While this phase is not abnormal and is a part of its mechanism of action, it is undesirable during surgery[citation needed], due to the inability to depolarize the cell again.[1] Often, patients must be on a ventilator for hours if Phase 2 block occurs.[citation needed] It generally occurs when suxamethonium is administered multiple times, or during an infusion occurring over too much time, but can also occur during an initial bolus if the plasma cholinesterase is abnormal[1] Desensitization may occur at the nerve terminal causing the myocyte to become less sensitive to acetylcholine, resulting in the membrane repolarizing and being unable be depolarized again for a period of time.[1]