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In page Central nervous system cavernous hemangioma:

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The incidence in the general population is roughly 0.5%, and clinical symptoms typically appear between 20 and 30 years of age.[1] Once thought to be strictly congenital, these vascular lesions have been found to occur de novo. It may appear either sporadically or exhibit autosomal dominant inheritance.[citation needed] The prevalence of familial CCM is estimated to be around 1 in 5000 to 1 in 10 000.[2]