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"

Detecting the Bombay phenotype in an individual is necessary in order to avoid complications during a blood transfusion, but the usual tests for the ABO blood group system would show them as group O. Since anti-H immunoglobulins can activate the complement cascade, it will lead to the lysis of red blood cells while they are still in the circulation, provoking an acute hemolytic transfusion reaction. This cannot be prevented unless those typing the blood and providing care are aware of the existence of the Bombay blood group and have the means to test for it.^{[citation needed]}

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