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In page Ataxia–telangiectasia:
"A–T is one of several DNA repair disorders that result in neurological abnormalities or degeneration. Arguably, some of the most devastating symptoms of A–T are a result of progressive cerebellar degeneration, characterized by the loss of Purkinje cells and, to a lesser extent, granule cells (located exclusively in the cerebellum).[1] The cause of this cell loss is unknown, though many hypotheses have been proposed based on experiments performed both in cell culture and in the mouse model of A–T.[citation needed]Current hypotheses explaining the neurodegeneration associated with A–T include the following:
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