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In page Chemical peel:

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Phenol used to be a deep chemical peel. Early phenol peel solutions were very painful and most practitioners would perform it under either general anesthesia, administered by an anesthesiologist or nurse anesthetist. Today it is more correctly referred to as a croton oil peel, since that has proven to be the active ingredient responsible for most of its effects.[citation needed] Recent formulations allow more variation in the depth of treatment, and allow its use under sedation either orally or intravenously, usually in conjunction with local anesthetic injections.