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In page Guatemala syphilis experiments:

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Rabbits had been used to test treatments for syphilis since the early 20th century, when Sahachiro Hata injected them with arsphenamine, which became known as "the magic bullet" for treating syphilis. They were later injected in the 1940s with penicillin as part of research into methods for preventing syphilis. Around this same time, there was a push by medical professionals, including the U.S. Surgeon General Thomas Parran, to further the knowledge of sexually transmitted diseases and discover more viable prophylaxis and treatment options in humans.[citation needed]