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In page Anna of Russia:

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As her health declined Anna declared her grandnephew, Ivan VI, as her successor and appointed Biron as regent. This was an attempt to secure the line of her father, Ivan V, and exclude the descendants of Peter the Great from inheriting the throne.[1] It was recorded that she had an ulcer on her kidneys,[2] and she continued having attacks of gout; as her condition worsened, her health began to fail.[citation needed]