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In page Isabella of Portugal:

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As Charles had planned, he appointed Isabella regent of Spain during his absence from the peninsula to lead his military campaigns and attend the administration of his other kingdoms between 1529–33 and 1537–39. She attended meetings of the governing councils and consulted with the ministers. As time passed, she took a more active role in the policy-making process, suggesting her own solutions rather than merely accepting recommendations. Her husband considered her deliberations "very prudent and well thought out".[citation needed] With both civil and criminal jurisdiction, Isabella appointed Diego López de Medrano as her mayordomo mayor (High Steward), entrusting him with the organization and governance of the royal palace.[1]