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In page Apoptosis:
"A cell undergoing apoptosis shows a series of characteristic morphological changes. Early alterations include:
- Cell shrinkage and rounding occur because of the retraction of lamellipodia and the breakdown of the proteinaceous cytoskeleton by caspases.[2]
- The cytoplasm appears dense, and the organelles appear tightly packed.[citation needed]
- Chromatin undergoes condensation into compact patches against the nuclear envelope (also known as the perinuclear envelope) in a process known as pyknosis, a hallmark of apoptosis.[3][4]
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