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In page Systemic scleroderma:

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Topical treatment for the skin changes of scleroderma do not alter the disease course, but may improve pain and ulceration. A range of nonsteroidal anti-inflammatory drugs, such as naproxen, can be used to ease painful symptoms.[citation needed] The benefit from steroids such as prednisone is limited.[citation needed] Episodes of Raynaud's phenomenon sometimes respond to nifedipine or other calcium channel blockers; severe digital ulceration may respond to prostacyclin analogue iloprost, and the dual endothelin-receptor antagonist bosentan may be beneficial for Raynaud's phenomenon.[1] Skin tightness may be treated systemically with methotrexate and ciclosporin.[1] and the skin thickness can be treated with penicillamine.