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In page Epigenetics:

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In the steady state (with endogenous damages occurring and being repaired), there are about 2,400 oxidatively damaged guanines that form 8-oxo-2'-deoxyguanosine (8-OHdG) in the average mammalian cell DNA.[1] 8-OHdG constitutes about 5% of the oxidative damages commonly present in DNA.[2] The oxidized guanines do not occur randomly among all guanines in DNA. There is a sequence preference for the guanine at a methylated CpG site (a cytosine followed by guanine along its 5' → 3' direction and where the cytosine is methylated (5-mCpG)).[3] A 5-mCpG site has the lowest ionization potential for guanine oxidation.[citation needed]