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In the 19th century, the United States government removed an estimated number of 100,000[1] Native Americans to federally-owned and -designated Indian reservations. Native Americans were removed from the Eastern to the Western States. The most well-known removals were those of the 1830s from the Southeast, starting with the Choctaw people. Under the 1830 Indian Removal Act, the Five Civilized Tribes were relocated from their place, east of the Mississippi River, to the Indian Territory in the west. The process resulted in great social dislocation for all, numerous deaths, and the "Trail of Tears" for the Cherokee Nation. Resistance to Indian removal led to several violent conflicts, including the Second Seminole War in Florida.[citation needed]