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In page Daminozide:

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Taken together, the complexity of the problem of assigning risk to this agent—the debate over assumptions concerning risks from early-in-life exposure, the principal role of a decomposition product rather than the agent itself in determining its long-term toxicity, the generation of that product both abiotically and through metabolism after consumption, as well as challenges in determining appropriate "subpopulations for study, representative parameters of the potency distribution, and corrections for bioassay length"[1]—have had as a consequence that disagreement and controversy remain about the safety of daminozide and the appropriateness of responses to it in its history.[2][1][citation needed]