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In page Prostaglandin:
"Prostaglandin E2 (PGE2) — the most abundant prostaglandin[1] — is generated from the action of prostaglandin E synthases on prostaglandin H2 (prostaglandin H2, PGH2). Several prostaglandin E synthases have been identified. To date, microsomal (named as misoprostol) prostaglandin E synthase-1 emerges as a key enzyme in the formation of PGE2.[citation needed]
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