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In page Fibroblast:
"Fibroblasts from different anatomical sites in the body express many genes that code for immune mediators and proteins.[1] These mediators of immune response enable the cellular communication with hematopoietic immune cells.[2] The immune activity of non-hematopoietic cells, such as fibroblasts, is referred to as “structural immunity”.[1][3] In order to facilitate a fast response to immunological challenges, fibroblasts encode crucial aspects of the structural cell immune response in the epigenome.[citation needed]
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