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In page Bioaccumulation:

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An example of poisoning in the workplace can be seen from the phrase "mad as a hatter" (18th and 19th century England). Mercury was used in stiffening the felt that was used to make hats. This forms organic species such as methylmercury, which is lipid-soluble (fat-soluble), and tends to accumulate in the brain, resulting in mercury poisoning. Other lipid-soluble poisons include tetraethyllead compounds (the lead in leaded petrol), and DDT. These compounds are stored in the body fat, and when the fatty tissues are used for energy, the compounds are released and cause acute poisoning.[citation needed]