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In page Opium:
"A range of synthetic opioids such as methadone (1937), pethidine (1939), fentanyl (late 1950s), and derivatives thereof have been introduced, and each is preferred for certain specialized applications. Nonetheless, morphine remains the drug of choice for American combat medics, who carry packs of syrettes containing 16 milligrams each for use on severely wounded soldiers.[7] No drug has been found that can match the painkilling effect of opioids without also duplicating much of their addictive potential.[citation needed]
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