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In page Nuclear fusion:

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From the period approximately 10 seconds to 20 minutes after the Big Bang, the universe cooled from over 100 keV to 1 keV. This allowed the combination of protons and neutrons in deuterium nuclei, and beginning a rapid fusion chain into tritium and helium-3 and ending in predominantly helium-4, with a minimal fraction of lithium, beryllium, and boron nuclei.[citation needed]