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Devices with R-290 refrigerant (propane) are expected to play a key role in the future.[7][18] The 100-year GWP of propane, at 0.02, is extremely low and is approximately 7000 times less than R-32. However, the flammability of propane requires additional safety measures: the maximum safe charges have been set significantly lower than for lower flammability refrigerants (only allowing approximately 13.5 times less refrigerant in the system than R-32).[19][20][21] This means that R-290 is not suitable for all situations or locations. Nonetheless, by 2022, an increasing number of devices with R-290 were offered for domestic use, especially in Europe.[citation needed]