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"Helium can be used either in place of, or mixed with, argon for plasma generation.[1][2] Helium's higher first ionisation energy allows greater ionisation and therefore higher sensitivity for hard-to-ionise elements. The use of pure helium also avoids argon-based interferences such as ArO.[3] However, many of the interferences can be mitigated by use of a collision cell, and the greater cost of helium has prevented its use in commercial ICP-MS.[citation needed]
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