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In page Single-stage-to-orbit:

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Due to weight issues such as shielding, many nuclear propulsion systems are unable to lift their own weight, and hence are unsuitable for launching to orbit. However, some designs such as the Orion project and some nuclear thermal designs do have a thrust to weight ratio in excess of 1, enabling them to lift off. Clearly, one of the main issues with nuclear propulsion would be safety, both during a launch for the passengers, but also in case of a failure during launch. As of December 2021, no current program is attempting nuclear propulsion from Earth's surface.[citation needed]