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In page Spanish colonization of the Americas:

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Native populations declined significantly during the period of Spanish expansion. In Hispaniola, the indigenous Taíno pre-contact population before the arrival of Columbus of several hundred thousand had declined to sixty thousand by 1509. The population of the Native American population in Mexico declined by an estimated 90% (reduced to 1–2.5 million people) by the early 17th century.[citation needed] In Peru, the indigenous Amerindian pre-contact population of around 6.5 million declined to 1 million by the early 17th century.[citation needed] The overwhelming cause of the decline in both Mexico and Peru was infectious diseases, such as smallpox and measles,[2] although the brutality of the encomienda also played a significant part in the population decline.[citation needed]