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In page Ion channel:

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Gating also includes activation and inactivation by second messengers from the inside of the cell membrane – rather than from outside the cell, as in the case for ligands.

  • Two-pore channels include ligand-gated and voltage-gated cation channels, so-named because they contain two pore-forming subunits. As their name suggests, they have two pores.[3][4][5][6][7]
  • Light-gated channels like channelrhodopsin are directly opened by photons.[citation needed]
  • Mechanosensitive ion channels open under the influence of stretch, pressure, shear, and displacement.[citation needed]