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In page Jacobaea vulgaris:

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Ragwort is of concern to people who keep horses and cattle.[2][3] In areas of the world where ragwort is a native plant, such as Britain and continental Europe, documented cases of proven poisoning are rare.[4] Horses do not normally eat fresh ragwort due to its taste.[citation needed][5] The result, if sufficient quantity is consumed, can be irreversible cirrhosis of the liver of a form identified as megalocytosis where cells are abnormally enlarged. Signs that a horse has been poisoned include yellow mucous membranes, depression, and lack of coordination.[6]