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In page Anxiolytic:
"The first tricyclic antidepressant, imipramine, was originally developed and studied to be an antihistamine alongside other first-generation antihistamines of the time, such as promethazine.[2] TCAs can increase the level of norepinephrine and serotonin by inhibiting their reuptake transport proteins.[3] The majority of TCAs exert greater effect on norepinephrine, which leads to side effects like drowsiness and memory loss.[citation needed]
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