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In page Flechette:

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Work at Johns Hopkins University in the 1950s led to the development of the direct injection antipersonnel chemical biological agent (DIACBA), where flechettes were grooved, hollow pointed, or otherwise milled to retain a quantity of chemical or biological warfare agent to be delivered through a ballistic wound.[1] The initial work was with the nerve agent VX, which had to be thickened to deliver a reliable dose. Eventually this was replaced by a highly toxic carbamate insecticide. The US Biological Program also had a microflechette to deliver either botulinum toxin A or saxitoxin, the M1 biodart, which resembled a 7.62 mm rifle cartridge. The USSR had the AO-27 rifle as well as the APS amphibious rifle, and other countries have their own flechette rounds.[citation needed]