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In page Alcohol dehydrogenase:

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There have been studies showing that variations in ADH that influence ethanol metabolism have an impact on the risk of alcohol dependence.[1][2][3][4][5] The strongest effect is due to variations in ADH1B that increase the rate at which alcohol is converted to acetaldehyde. One such variant is most common in individuals from East Asia and the Middle East, another is most common in individuals from Africa.[2] Both variants reduce the risk for alcoholism, but individuals can become alcoholic despite that. Researchers have tentatively detected a few other genes to be associated with alcoholism, and know that there must be many more remaining to be found.[6] Research continues in order to identify the genes and their influence on alcoholism.[citation needed]