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In page Paregoric:

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However, Paregoric was characterized as "a needlessly complex pharmacopeial mixture... of a former day" by a 1966 study.[2] In the 21st century its two main uses have been largely supplanted by minimally psychoactive cough-suppressant drugs (such as dextromethorphan) and non-psychoactive antidiarrheal drugs (such as loperamide).[citation needed]